Thiol Redox Chemistry: Role of Protein Cysteine Oxidation and Altered Redox Homeostasis in Allergic Inflammation and Asthma

Thiol-based redox homeostasis and signaling

1 Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas, Sevilla, Spain 2 INRES Chemical Signalling, University of Bonn, Bonn, Germany 3 Laboratoire Génome et Développement des Plantes, Université Perpignan Via Domitia, Perpignan, France 4 Laboratoire Génome et Développement des Plantes, CNRS, Perpignan, France 5 Faculté des Scie...

Thiol redox homeostasis in neurodegenerative disease

This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc(-) cystine-glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's dise...

Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes

This review discusses the current understanding of cysteine and glutathione redox balance in astrocytes. Particular emphasis is placed on the impact of oxidative stress and astrocyte activation on pathways that provide cysteine as a precursor for glutathione. The effect of the disruption of thiol-containing amino acid metabolism on the antioxidant capacity of astrocytes is also discussed.

Rosics: Chemistry and Proteomics of Cysteine Modifications in Redox Biology

Post-translational modifications (PTMs) occurring in proteins determine their functions and regulations. Proteomic tools are available to identify PTMs and have proved invaluable to expanding the inventory of these tools of nature that hold the keys to biological processes. Cysteine (Cys), the least abundant (1-2%) of amino acid residues, are unique in that they play key roles in maintaining st...

Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery